• Western blot analysis of various lysates, using Folate Binding Protein (FBP) / FOLR1 Rabbit PolymAb® (STJ11104857) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
  • Western blot analysis of extracts from HeLa cells, using Folate Binding Protein (FBP) / FOLR1 Rabbit PolymAb® (STJ11104857) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-FOLR1 antibody (1-100) [S4857RM] (STJ11104857)

SKU:
STJ11104857

£146.50 - £639.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Folate Receptor Alpha (1-100) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4857RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FOLR1
Gene ID: 2348
Uniprot ID: FOLR1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein (FBP) /FOLR1 (NP_000793.1).
Immunogen Sequence: MAQRMTTQLLLLLVWVAVVG EAQTRIAWARTELLNVCMNA KHHKEKPGPEDKLHEQCRPW RKNACCSTNTSQEAHKDVSY LYRFNWNHCGEMAPACKRHF
Tissue Specificity Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name Folate Receptor Alpha
Fr-Alpha
Adult Folate-Binding Protein
Fbp
Folate Receptor 1
Folate Receptor - Adult
Kb Cells Fbp
Ovarian Tumor-Associated Antigen Mov18
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Antibody Names Anti-Folate Receptor Alpha antibody
Anti-Fr-Alpha antibody
Anti-Adult Folate-Binding Protein antibody
Anti-Fbp antibody
Anti-Folate Receptor 1 antibody
Anti-Folate Receptor - Adult antibody
Anti-Kb Cells Fbp antibody
Anti-Ovarian Tumor-Associated Antigen Mov18 antibody
Anti-FOLR1 antibody
Anti-FOLR antibody

Information sourced from Uniprot.org

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