Anti-FMO2 antibody (210-470) (STJ115916)

SKU:
STJ115916

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FMO2 (210-470) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FMO2
Gene ID: 2327
Uniprot ID: FMO2_HUMAN
Immunogen Region: 210-470
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2).
Immunogen Sequence: VFISTRHGTWVMSRISEDGY PWDSVFHTRFRSMLRNVLPR TAVKWMIEQQMNRWFNHENY GLEPQNKYIMKEPVLNDDVP SRLLCGAIKVKSTVKELTET SAIFEDGTVEENIDVIIFAT GYSFSFPFLEDSLVKVENNM VSLYKYIFPAHLDKSTLACI GLIQPLGSIFPTAELQARWV TRVFKGLCSLPSERTMMMDI IKRNEKRIDLFGESQSQTLQ TNYVDYLDELALEIGAKPD
Tissue Specificity Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
Function Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton.
Protein Name Flavin-Containing Monooxygenase 2
Dimethylaniline Oxidase 2
Fmo 1b1
Pulmonary Flavin-Containing Monooxygenase 2
Fmo 2
Database Links Reactome: R-HSA-217271
Cellular Localisation Microsome Membrane
Single-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Flavin-Containing Monooxygenase 2 antibody
Anti-Dimethylaniline Oxidase 2 antibody
Anti-Fmo 1b1 antibody
Anti-Pulmonary Flavin-Containing Monooxygenase 2 antibody
Anti-Fmo 2 antibody
Anti-FMO2 antibody

Information sourced from Uniprot.org

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