| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FMO1 (363-532) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FMO1 |
| Gene ID: |
2326 |
| Uniprot ID: |
FMO1_HUMAN |
| Immunogen Region: |
363-532 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 363-532 of human FMO1 (NP_002012.1). |
| Immunogen Sequence: |
KPTLAIIGLIKPLGSMIPTG ETQARWAVRVLKGVNKLPPP SVMIEEINARKENKPSWFGL CYCKALQSDYITYIDELLTY INAKPNLFSMLLTDPHLALT VFFGPCSPYQFRLTGPGKWE GARNAIMTQWDRTFKVIKAR VVQESPSPFESFLKVFSFLA LLVAIFLIFL |
| Tissue Specificity | Expressed mainly in fetal and adult liver. |
| Function | Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. |
| Protein Name | Flavin-Containing Monooxygenase 1Dimethylaniline Monooxygenase N-Oxide-Forming 1Dimethylaniline Oxidase 1Fetal Hepatic Flavin-Containing Monooxygenase 1Fmo 1Trimethylamine Monooxygenase |
| Database Links | Reactome: R-HSA-1614558Reactome: R-HSA-217271 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 1 antibodyAnti-Dimethylaniline Monooxygenase N-Oxide-Forming 1 antibodyAnti-Dimethylaniline Oxidase 1 antibodyAnti-Fetal Hepatic Flavin-Containing Monooxygenase 1 antibodyAnti-Fmo 1 antibodyAnti-Trimethylamine Monooxygenase antibodyAnti-FMO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Adenosine Deaminase (Adenosine Deaminase (ADA) ) knockout (KO) HeLa cells, using [KO Validated] Adenosine Deaminase (ADA) Rabbit polyclonal antibody (STJ11100002) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89075/357532/STJ11100002_1__24167.1713121647.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Adenosine Deaminase (Adenosine Deaminase (ADA) ) knockout (KO) HeLa cells, using [KO Validated] Adenosine Deaminase (ADA) Rabbit polyclonal antibody (STJ11100002) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")
