| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FLOT2 (239-428) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLOT2 |
| Gene ID: |
2319 |
| Uniprot ID: |
FLOT2_HUMAN |
| Immunogen Region: |
239-428 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 239-428 of human FLOT2 (NP_004466.2). |
| Immunogen Sequence: |
LAYELQGAREQQKIRQEEIE IEVVQRKKQIAVEAQEILRT DKELIATVRRPAEAEAHRIQ QIAEGEKVKQVLLAQAEAEK IRKIGEAEAAVIEAMGKAEA ERMKLKAEAYQKYGDAAKMA LVLEALPQIAAKIAAPLTKV DEIVVLSGDNSKVTSEVNRL LAELPASVHALTGVDLSKIP LIKKATGVQV |
| Tissue Specificity | In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. |
| Post Translational Modifications | ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells. |
| Function | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Protein Name | Flotillin-2Epidermal Surface AntigenEsaMembrane Component Chromosome 17 Surface Marker 1 |
| Database Links | Reactome: R-HSA-5213460Reactome: R-HSA-5675482Reactome: R-HSA-8849932Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinMembraneCaveolaEndosomeLipid-AnchorMembrane-Associated Protein Of Caveolae |
| Alternative Antibody Names | Anti-Flotillin-2 antibodyAnti-Epidermal Surface Antigen antibodyAnti-Esa antibodyAnti-Membrane Component Chromosome 17 Surface Marker 1 antibodyAnti-FLOT2 antibodyAnti-ESA1 antibodyAnti-M17S1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
