| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FFAR1 (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FFAR1 |
| Gene ID: |
2864 |
| Uniprot ID: |
FFAR1_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FFAR1 (NP_005294.1). |
| Immunogen Sequence: |
FCYVGCLRALARSGLTHRRK LRAAWVAGGALLTLLLCVGP YNASNVASFLYPNLGGSWRK LGLITGAWSVVLNPLVTGYL GRGPGLKTVCAARTQGGKSQ K |
| Tissue Specificity | Detected in brain and pancreas. Detected in pancreatic beta cells. |
| Function | G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis.receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. |
| Protein Name | Free Fatty Acid Receptor 1G-Protein Coupled Receptor 40 |
| Database Links | Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-416476Reactome: R-HSA-434316Reactome: R-HSA-444209 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Free Fatty Acid Receptor 1 antibodyAnti-G-Protein Coupled Receptor 40 antibodyAnti-FFAR1 antibodyAnti-GPR40 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
