Western blot analysis of various lysates using FE <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 20s.

Anti-FERMT3 antibody (1-270) (STJ110149)

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STJ110149
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FERMT3
Gene ID: 83706
Uniprot ID: URP2_HUMAN
Immunogen Region: 1-270
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human FERMT3 (NP_113659.3).
Immunogen Sequence: MAGMKTASGDYIDSSWELRV FVGEEDPEAESVTLRVTGES HIGGVLLKIVEQINRKQDWS DHAIWWEQKRQWLLQTHWTL DKYGILADARLFFGPQHRPV ILRLPNRRALRLRASFSQPL FQAVAAICRLLSIRHPEELS LLRAPEKKEKKKKEKEPEEE LYDLSKVVLAGGVAPALFRG MPAHFSDSAQTEACYHMLSR PQPPPDPLLLQRLPRPSSLS DKTQLHSRWLDSSRCLMQQ
Tissue Specificity Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
Function Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
Protein Name Fermitin Family Homolog 3
Kindlin-3
Mig2-Like Protein
Unc-112-Related Protein 2
Database Links Reactome: R-HSA-114608
Cellular Localisation Cell Projection
Podosome
Present In The F-Actin Surrounding Ring Structure Of Podosomes
Which Are Specialized Adhesion Structures Of Hematopoietic Cells
Alternative Antibody Names Anti-Fermitin Family Homolog 3 antibody
Anti-Kindlin-3 antibody
Anti-Mig2-Like Protein antibody
Anti-Unc-112-Related Protein 2 antibody
Anti-FERMT3 antibody
Anti-KIND3 antibody
Anti-MIG2B antibody
Anti-URP2 antibody

Information sourced from Uniprot.org

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