| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FERMT3 (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FERMT3 |
| Gene ID: |
83706 |
| Uniprot ID: |
URP2_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human FERMT3 (NP_113659.3). |
| Immunogen Sequence: |
MAGMKTASGDYIDSSWELRV FVGEEDPEAESVTLRVTGES HIGGVLLKIVEQINRKQDWS DHAIWWEQKRQWLLQTHWTL DKYGILADARLFFGPQHRPV ILRLPNRRALRLRASFSQPL FQAVAAICRLLSIRHPEELS LLRAPEKKEKKKKEKEPEEE LYDLSKVVLAGGVAPALFRG MPAHFSDSAQTEACYHMLSR PQPPPDPLLLQRLPRPSSLS DKTQLHSRWLDSSRCLMQQ |
| Tissue Specificity | Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies. |
| Function | Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. |
| Protein Name | Fermitin Family Homolog 3Kindlin-3Mig2-Like ProteinUnc-112-Related Protein 2 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Cell ProjectionPodosomePresent In The F-Actin Surrounding Ring Structure Of PodosomesWhich Are Specialized Adhesion Structures Of Hematopoietic Cells |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 3 antibodyAnti-Kindlin-3 antibodyAnti-Mig2-Like Protein antibodyAnti-Unc-112-Related Protein 2 antibodyAnti-FERMT3 antibodyAnti-KIND3 antibodyAnti-MIG2B antibodyAnti-URP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
