| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FCN3 |
| Gene ID: | 8547 |
| Uniprot ID: | FCN3_HUMAN |
| Immunogen Region: | 13-288 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 13-288 of human FCN3 (NP_775628.1). |
| Immunogen Sequence: | LLLGGPACLKTQEHPSCPGP RELEASKVVLLPSCPGAPGS PGEKGAPGPQGPPGPPGKMG PKGEPGPRNCRELLSQGATL SGWYHLCLPEGRALPVFCDM DTEGGGWLVFQRRQDGSVDF FRSWSSYRAGFGNQESEFWL GNENLHQLTLQGNWELRVEL EDFNGNRTFAHYATFRLLGE VDHYQLALGKFSEGTAGDSL SLHSGRPFTTYDADHDSSNS NCAVIVHGAWWYASCYRSN |
| Tissue Specificity | Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. |
| Protein Name | Ficolin-3 Collagen/Fibrinogen Domain-Containing Lectin 3 P35 Collagen/Fibrinogen Domain-Containing Protein 3 Hakata Antigen |
| Database Links | Reactome: R-HSA-166662 Reactome: R-HSA-166663 Reactome: R-HSA-2855086 |
| Cellular Localisation | Secreted Found In Blood Plasma Bronchus Alveolus And Bile Duct |
| Alternative Antibody Names | Anti-Ficolin-3 antibody Anti-Collagen/Fibrinogen Domain-Containing Lectin 3 P35 antibody Anti-Collagen/Fibrinogen Domain-Containing Protein 3 antibody Anti-Hakata Antigen antibody Anti-FCN3 antibody Anti-FCNH antibody Anti-HAKA1 antibody |
Information sourced from Uniprot.org