• Western blot analysis of extracts of mouse thymus, using FANCE antibody (STJ110715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
  • Western blot analysis of extracts of mouse thymus, using FANCE antibody (STJ110715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-FANCE antibody (1-255) (STJ110715)

SKU:
STJ110715

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FANCE (1-255) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FANCE
Gene ID: 2178
Uniprot ID: FANCE_HUMAN
Immunogen Region: 1-255
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human FANCE (NP_068741.1).
Immunogen Sequence: MATPDAGLPGAEGVEPAPWA QLEAPARLLLQALQAGPEGA RRGLGVLRALGSRGWEPFDW GRLLEALCREEPVVQGPDGR LELKPLLLRLPRICQRNLMS LLMAVRPSLPESGLLSVLQI AQQDLAPDPDAWLRALGELL RRDLGVGTSMEGASPLSERC QRQLQSLCRGLGLGGRRLKS PQAPDPEEEENRDSQQPGKR RKDSEEEAASPEGKRVPKRL RCWEEEEDHEKERPEHKSL
Post Translational Modifications Phosphorylated. Phosphorylation by CHEK1 at Thr-346 and Ser-374 regulates its function in DNA cross-links repair. Ubiquitinated. Phosphorylation by CHEK1 induces polyubiquitination and degradation.
Function As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.
Protein Name Fanconi Anemia Group E Protein
Protein Face
Database Links Reactome: R-HSA-6783310
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Fanconi Anemia Group E Protein antibody
Anti-Protein Face antibody
Anti-FANCE antibody
Anti-FACE antibody

Information sourced from Uniprot.org

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