| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Fanconi-associated nuclease 1 (801-851 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FAN1 |
| Gene ID: |
22909 |
| Uniprot ID: |
FAN1_HUMAN |
| Immunogen Region: |
801-851 aa |
| Specificity: |
This antibody detects endogenous levels of FAN1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human FAN1 at the amino acid range 801-851 |
| Function | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps. |
| Protein Name | Fanconi-Associated Nuclease 1Fancd2/Fanci-Associated Nuclease 1Hfan1Myotubularin-Related Protein 15 |
| Database Links | Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage Following Recruitment By Monoubiquitinated Fancd2Localizes To Stalled Replication Forks Via Its Ubz4-Type Zinc Finger |
| Alternative Antibody Names | Anti-Fanconi-Associated Nuclease 1 antibodyAnti-Fancd2/Fanci-Associated Nuclease 1 antibodyAnti-Hfan1 antibodyAnti-Myotubularin-Related Protein 15 antibodyAnti-FAN1 antibodyAnti-KIAA1018 antibodyAnti-MTMR15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
