| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RIPOR1 |
| Gene ID: | 79567 |
| Uniprot ID: | RIPR1_HUMAN |
| Immunogen Region: | 1004-1223 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1004-1223 of human FAM65A (NP_001180451.1). |
| Immunogen Sequence: | LSLRQPGLAEAVCVKFLEDA LGQKLPRRPQPGPGEQLTVF QFWSFVETLDSPTMEAYVTE TAEEVLLVRNLNSDDQAVVL KALRLAPEGRLRRDGLRALS SLLVHGNNKVMAAVSTQLRS LSLGPTFRERALLCFLDQLE DEDVQTRVAGCLALGCIKAP EGIEPLVYLCQTDTEAVREA ARQSLQQCGEEGQSAHRRLE ESLDALPRIFGPGSMASTAF |
| Function | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation. |
| Protein Name | Rho Family-Interacting Cell Polarization Regulator 1 |
| Cellular Localisation | CytoplasmGolgi ApparatusLocalizes To The Podocyte Major Processes And Cell BodyColocalized With Stk26 In The Golgi Of Serum-Starved Cells And Relocated To Cytoplasmic PunctaeProbably Vesicular CompartmentsAlong With Stk26 Upon Serum Stimulation In A Rho- And Pdcd10-Dependent Manner |
| Alternative Antibody Names | Anti-Rho Family-Interacting Cell Polarization Regulator 1 antibodyAnti-RIPOR1 antibodyAnti-FAM65A antibodyAnti-KIAA1930 antibody |
Information sourced from Uniprot.org