| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:100-1:200IF/ICC:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FAM3B |
| Gene ID: | 54097 |
| Uniprot ID: | FAM3B_HUMAN |
| Immunogen Region: | 30-235 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human FAM3B (NP_478066.3). |
| Immunogen Sequence: | ELIPDAPLSSAAYSIRSIGE RPVLKAPVPKRQKCDHWTPC PSDTYAYRLLSGGGRSKYAK ICFEDNLLMGEQLGNVARGI NIAIVNYVTGNVTATRCFDM YEGDNSGPMTKFIQSAAPKS LLFMVTYDDGSTRLNNDAKN AIEALGSKEIRNMKFRSSWV FIAAKGLELPSEIQREKINH SDAKNNRYSGWPAEIQIEGC IPKERS |
| Tissue Specificity | Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. |
| Post Translational Modifications | 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. O-glycosylated. |
| Function | Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. |
| Protein Name | Protein Fam3bCytokine-Like Protein 2-21Pancreatic-Derived FactorPander |
| Cellular Localisation | SecretedPresent In Insulin Secretory Granules And Likely Cosecreted With InsulinLocalized In Discrete Vesicular And Perinuclear Structure |
| Alternative Antibody Names | Anti-Protein Fam3b antibodyAnti-Cytokine-Like Protein 2-21 antibodyAnti-Pancreatic-Derived Factor antibodyAnti-Pander antibodyAnti-FAM3B antibodyAnti-C21orf11 antibodyAnti-C21orf76 antibodyAnti-PRED44 antibodyAnti-UNQ320 antibodyAnti-PRO365 antibody |
Information sourced from Uniprot.org