| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-F7 (240-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F7 |
| Gene ID: |
2155 |
| Uniprot ID: |
FA7_HUMAN |
| Immunogen Region: |
240-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human F7 (NP_062562.1). |
| Immunogen Sequence: |
RNLIAVLGEHDLSEHDGDEQ SRRVAQVIIPSTYVPGTTNH DIALLRLHQPVVLTDHVVPL CLPERTFSERTLAFVRFSLV SGWGQLLDRGATALELMVLN VPRLMTQDCLQQSRKVGDSP NITEYMFCAGYSDGSKDSCK GDSGGPHATHYRGTWYLTGI V |
| Tissue Specificity | Plasma. |
| Post Translational Modifications | The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-S/T-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro. |
| Function | Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. |
| Protein Name | Coagulation Factor ViiProconvertinSerum Prothrombin Conversion AcceleratorSpcaEptacog Alfa Cleaved Into - Factor Vii Light Chain - Factor Vii Heavy Chain |
| Database Links | Reactome: R-HSA-1368108Reactome: R-HSA-140834Reactome: R-HSA-159740Reactome: R-HSA-159763Reactome: R-HSA-159782 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor Vii antibodyAnti-Proconvertin antibodyAnti-Serum Prothrombin Conversion Accelerator antibodyAnti-Spca antibodyAnti-Eptacog Alfa Cleaved Into - Factor Vii Light Chain - Factor Vii Heavy Chain antibodyAnti-F7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
