| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EXOC1 |
| Gene ID: | 55763 |
| Uniprot ID: | EXOC1_HUMAN |
| Immunogen Region: | 645-894 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 645-894 of human EXOC1 (NP_001020095.1). |
| Immunogen Sequence: | RNFDKCISNQIRQMEEVKIS KKSKVGILPFVAEFEEFAGL AESIFKNAERRGDLDKAYTK LIRGVFVNVEKVANESQKTP RDVVMMENFHHIFATLSRLK ISCLEAEKKEAKQKYTDHLQ SYVIYSLGQPLEKLNHFFEG VEARVAQGIREEEVSYQLAF NKQELRKVIKEYPGKEVKKG LDNLYKKVDKHLCEEENLLQ VVWHSMQDEFIRQYKHFEGL IARCYPGSGVTMEFTIQDI |
| Function | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. |
| Protein Name | Exocyst Complex Component 1Exocyst Complex Component Sec3 |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-264876Reactome: R-HSA-5620916 |
| Cellular Localisation | MidbodyMidbody RingCytoplasmPerinuclear RegionCell MembraneColocalizes With Cntrl/Centriolin At The Midbody RingLocalizes In Cell Membrane In The Presence Of Slc6a9 |
| Alternative Antibody Names | Anti-Exocyst Complex Component 1 antibodyAnti-Exocyst Complex Component Sec3 antibodyAnti-EXOC1 antibodyAnti-SEC3 antibodyAnti-SEC3L1 antibodyAnti-BM-012 antibody |
Information sourced from Uniprot.org