| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FAM62B (630-760) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ESYT2 |
| Gene ID: |
57488 |
| Uniprot ID: |
ESYT2_HUMAN |
| Immunogen Region: |
630-760 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 630-760 of human FAM62B (NP_065779.1). |
| Immunogen Sequence: |
EKRERPPDHQHSAQVKRPSV SKEGRKTSIKSHMSGSPGPG GSNTAPSTPVIGGSDKPGME EKAQPPEAGPQGLHDLGRSS SSLLASPGHISVKEPTPSIA SDISLPIATQELRQRLRQLE NGTTLGQSPLG |
| Tissue Specificity | Widely expressed with high level in cerebellum. |
| Function | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding.this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS). |
| Protein Name | Extended Synaptotagmin-2E-Syt2Chr2syt |
| Database Links | Reactome: R-HSA-1660662 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLocalizes To Endoplasmic Reticulum-Plasma Membrane Contact Sites (Epcs)Recruited To The Cell Membrane Via The Third C2 Domain |
| Alternative Antibody Names | Anti-Extended Synaptotagmin-2 antibodyAnti-E-Syt2 antibodyAnti-Chr2syt antibodyAnti-ESYT2 antibodyAnti-FAM62B antibodyAnti-KIAA1228 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
