| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBR5 (550-760) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBR5 |
| Gene ID: |
51366 |
| Uniprot ID: |
UBR5_HUMAN |
| Immunogen Region: |
550-760 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 550-760 of human UBR5 (NP_056986.2). |
| Immunogen Sequence: |
SISAGIPKVGVLMESVWNMN DSCRFQLRSPESLKNMEKAS KTTEAKPESKQEPVKTEMGP PPSPASTCSDASSIASSASM PYKRRRSTPAPKEEEKVNEE QWSLREVVFVEDVKNVPVGK VLKVDGAYVAVKFPGTSSNT NCQNSSGPDADPSSLLQDCR LLRIDELQVVKTGGTPKVPD CFQRTPKKLCIPEKTEILAV NVDSKGVHAVL |
| Tissue Specificity | Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ubr5E3 Ubiquitin-Protein Ligase - Hect Domain-Containing 1Hect-Type E3 Ubiquitin Transferase Ubr5Hyperplastic Discs Protein HomologHhydProgestin-Induced Protein |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ubr5 antibodyAnti-E3 Ubiquitin-Protein Ligase - Hect Domain-Containing 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Ubr5 antibodyAnti-Hyperplastic Discs Protein Homolog antibodyAnti-Hhyd antibodyAnti-Progestin-Induced Protein antibodyAnti-UBR5 antibodyAnti-EDD antibodyAnti-EDD1 antibodyAnti-HYD antibodyAnti-KIAA0896 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
