| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-ErbB 3 (1094-1111 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | R05-3F7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/ml |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | ERBB3 |
| Gene ID: | 2065 |
| Uniprot ID: | ERBB3_HUMAN |
| Immunogen Region: | 1094-1111 aa |
| Immunogen: | A synthetic peptide of human ErbB 3 |
| Tissue Specificity | Epithelial tissues and brain. |
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3Proto-Oncogene-Like Protein C-Erbb-3Tyrosine Kinase-Type Cell Surface Receptor Her3 |
| Database Links | Reactome: R-HSA-1227986 P21860-1Reactome: R-HSA-1236394 P21860-1Reactome: R-HSA-1250196 P21860-1Reactome: R-HSA-1257604 P21860-1Reactome: R-HSA-1306955 P21860-1Reactome: R-HSA-1358803 P21860-1Reactome: R-HSA-1963642 P21860-1Reactome: R-HSA-2219530 P21860-1Reactome: R-HSA-5673001 P21860-1Reactome: R-HSA-6785631 P21860-1Reactome: R-HSA-6811558 P21860-1Reactome: R-HSA-8847993 P21860-1Reactome: R-HSA-8863795 P21860-1Reactome: R-HSA-9664565 P21860-1Reactome: R-HSA-9665686 P21860-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibodyAnti-Proto-Oncogene-Like Protein C-Erbb-3 antibodyAnti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibodyAnti-ERBB3 antibodyAnti-HER3 antibody |
Information sourced from Uniprot.org