| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EPHB4 (300-540) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EPHB4 |
| Gene ID: |
2050 |
| Uniprot ID: |
EPHB4_HUMAN |
| Immunogen Region: |
300-540 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-540 of human EPHB4 (NP_004435.3). |
| Immunogen Sequence: |
AVCQCRVGYFRARTDPRGAP CTTPPSAPRSVVSRLNGSSL HLEWSAPLESGGREDLTYAL RCRECRPGGSCAPCGGDLTF DPGPRDLVEPWVVVRGLRPD FTYTFEVTALNGVSSLATGP VPFEPVNVTTDREVPPAVSD IRVTRSSPSSLSLAWAVPRA PSGAVLDYEVKYHEKGAEGP SSVRFLKTSENRAELRGLKR GASYLVQVRARSEAGYGPFG QEHHSQTQLDESEGWREQL |
| Tissue Specificity | Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. |
| Post Translational Modifications | Phosphorylated.autophosphorylation is stimulated by EFNB2. |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. |
| Protein Name | Ephrin Type-B Receptor 4Hepatoma Transmembrane KinaseTyrosine-Protein Kinase Tyro11 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Ephrin Type-B Receptor 4 antibodyAnti-Hepatoma Transmembrane Kinase antibodyAnti-Tyrosine-Protein Kinase Tyro11 antibodyAnti-EPHB4 antibodyAnti-HTK antibodyAnti-MYK1 antibodyAnti-TYRO11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
