• Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using CD105/Endoglin Rabbit monoclonal antibody (STJ11101546) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0. 01M Tris-EDTA Buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of paraffin-embedded Human prostate tissue using CD105/Endoglin Rabbit monoclonal antibody (STJ11101546) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0. 01M Tris-EDTA Buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of paraffin-embedded Human placenta tissue using CD105/Endoglin Rabbit monoclonal antibody (STJ11101546) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0. 01M Tris-EDTA Buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of paraffin-embedded Human breast cancer tissue using CD105/Endoglin Rabbit monoclonal antibody (STJ11101546) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0. 01M Tris-EDTA Buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of paraffin-embedded Human liver tissue using CD105/Endoglin Rabbit monoclonal antibody (STJ11101546) at a dilution of 1:10000 (40x lens). High pressure antigen retrieval performed with 0. 01M Tris-EDTA Buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Western blot analysis of lysates from HUVEC cells, using CD105/Endoglin Rabbit monoclonal antibody (STJ11101546) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-ENG antibody (1-200) [S6MR] (STJ11101546)

SKU:
STJ11101546

£146.50 - £639.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CD105 (1-200) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ENG
Gene ID: 2022
Uniprot ID: EGLN_HUMAN
Immunogen Region: 1-200
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CD105/Endoglin (P17813).
Immunogen Sequence: MDRGTLPLAVALLLASCSLS PTSLAETVHCDLQPVGPERG EVTYTTSQVSKGCVAQAPNA ILEVHVLFLEFPTGPSQLEL TLQASKQNGTWPREVLLVLS VNSSVFLHLQALGIPLHLAY NSSLVTFQEPPGVNTTELPS FPKTQILEWAAERGPITSAA ELNDPQSILLRLGQAQGSLS FCMLEASQDMGRTLEWRPRT
Tissue Specificity Detected on umbilical veil endothelial cells. Detected in placenta (at protein level). Detected on endothelial cells.
Function Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
Protein Name Endoglin
Cd Antigen Cd105
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Endoglin antibody
Anti-Cd Antigen Cd105 antibody
Anti-ENG antibody
Anti-END antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance