| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ENC1 (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ENC1 |
| Gene ID: |
8507 |
| Uniprot ID: |
ENC1_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ENC1 (NP_003624.1). |
| Immunogen Sequence: |
MSVSVHENRKSRASSGSINI YLFHKSSYADSVLTHLNLLR QQRLFTDVLLHAGNRTFPCH RAVLAACSRYFEAMFSGGLK ESQDSEVNFDNSIHPEVLEL LLDYAYSSRVIINEENAESL LEAGDMLEFQDIRDACAEFL EKNLHPTNCLGMLLLSDAHQ CTKLYELSWRMCLSNFQTIR KNEDFLQLPQDMVVQLLSSE ELETEDERLVYESAINWISY DLKKRYCYLPELLQTVRLA |
| Tissue Specificity | Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma tumors. |
| Post Translational Modifications | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. |
| Function | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. |
| Protein Name | Ectoderm-Neural Cortex Protein 1Enc-1Kelch-Like Protein 37Nuclear Matrix Protein Nrp/BP53-Induced Gene 10 Protein |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Ectoderm-Neural Cortex Protein 1 antibodyAnti-Enc-1 antibodyAnti-Kelch-Like Protein 37 antibodyAnti-Nuclear Matrix Protein Nrp/B antibodyAnti-P53-Induced Gene 10 Protein antibodyAnti-ENC1 antibodyAnti-KLHL37 antibodyAnti-NRPB antibodyAnti-PIG10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
