Host: | Mouse |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-Eukaryotic translation initiation factor 4E-binding protein 1 is suitable for use in Western Blot and ELISA research applications. |
Clonality: | Monoclonal |
Clone ID: | 9E12D9 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EIF4EBP1 |
Gene ID: | 1978 |
Uniprot ID: | 4EBP1_HUMAN |
Specificity: | 4E-BP1 Monoclonal Antibody detects endogenous levels of 4E-BP1 protein. |
Immunogen: | Purified recombinant fragment of 4E-BP1 expressed in E. Coli. |
Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 4e-Bp1 Eif4e-Binding Protein 1 Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 Phas-I |
Database Links | Reactome: R-HSA-166208 Reactome: R-HSA-72662 |
Cellular Localisation | Cytoplasm Nucleus Localization To The Nucleus Is Unaffected By Phosphorylation Status |
Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 antibody Anti-4e-Bp1 antibody Anti-Eif4e-Binding Protein 1 antibody Anti-Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 antibody Anti-Phas-I antibody Anti-EIF4EBP1 antibody |
Information sourced from Uniprot.org