| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DUSP1/MKP1 (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DUSP1 |
| Gene ID: |
1843 |
| Uniprot ID: |
DUS1_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human DUSP1/MKP1 (NP_004408.1). |
| Immunogen Sequence: |
MVMEVGTLDAGGLRALLGER AAQCLLLDCRSFFAFNAGHI AGSVNVRFSTIVRRRAKGAM GLEHIVPNAELRGRLLAGAY HAVVLLDERSAALDGAKRDG TLALAAGALCREARAAQVFF LKGGYEAFSASCPELCSKQS TPMGLSLPLSTSVPDSAESG |
| Tissue Specificity | Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. |
| Post Translational Modifications | Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. |
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Protein Name | Dual Specificity Protein Phosphatase 1Dual Specificity Protein Phosphatase Hvh1Mitogen-Activated Protein Kinase Phosphatase 1Map Kinase Phosphatase 1Mkp-1Protein-Tyrosine Phosphatase Cl100 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 1 antibodyAnti-Dual Specificity Protein Phosphatase Hvh1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 1 antibodyAnti-Map Kinase Phosphatase 1 antibodyAnti-Mkp-1 antibodyAnti-Protein-Tyrosine Phosphatase Cl100 antibodyAnti-DUSP1 antibodyAnti-CL100 antibodyAnti-MKP1 antibodyAnti-PTPN10 antibodyAnti-VH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
