| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DUOX1 |
| Gene ID: |
53905 |
| Uniprot ID: |
DUOX1_HUMAN |
| Immunogen Region: |
1312-1551 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1312-1551 of human DUOX1 (NP_059130.2). |
| Immunogen Sequence: |
ALGTTEYHPFTLTSAPHEDT LSLHIRAAGPWTTRLREIYS APTGDRCARYPKLYLDGPFG EGHQEWHKFEVSVLVGGGIG VTPFASILKDLVFKSSVSCQ VFCKKIYFIWVTRTQRQFEW LADIIREVEENDHQDLVSVH IYITQLAEKFDLRTTMLYIC ERHFQKVLNRSLFTGLRSIT HFGRPPFEPFFNSLQEVHPQ VRKIGVFSCGPPGMTKNVEK ACQLINRQDRTHFSHHYEN |
| Tissue Specificity | Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. |
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 1Large Nox 1Long Nox 1Nadph Thyroid Oxidase 1Thyroid Oxidase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalizes To The Apical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Dual Oxidase 1 antibodyAnti-Large Nox 1 antibodyAnti-Long Nox 1 antibodyAnti-Nadph Thyroid Oxidase 1 antibodyAnti-Thyroid Oxidase 1 antibodyAnti-DUOX1 antibodyAnti-DUOX antibodyAnti-LNOX1 antibodyAnti-THOX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
