| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DSTYK (635-884) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DSTYK |
| Gene ID: |
25778 |
| Uniprot ID: |
DUSTY_HUMAN |
| Immunogen Region: |
635-884 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 635-884 of human DSTYK (NP_955749.1). |
| Immunogen Sequence: |
RLSLESCSLQDVLLHRKPKL GQELGRGQYGVVYLCDNWGG HFPCALKSVVPPDEKHWNDL ALEFHYMRSLPKHERLVDLH GSVIDYNYGGGSSIAVLLIM ERLHRDLYTGLKAGLTLETR LQIALDVVEGIRFLHSQGLV HRDIKLKNVLLDKQNRAKIT DLGFCKPEAMMSGSIVGTPI HMAPELFTGARPERLPVFDE ECWQLMEACWDGDPLKRPLL GIVQPMLQGIMNRLCKSNS |
| Tissue Specificity | Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin. |
| Function | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. |
| Protein Name | Dual Serine/Threonine And Tyrosine Protein KinaseDusty Protein KinaseDusty PkRip-Homologous KinaseReceptor-Interacting Serine/Threonine-Protein Kinase 5Sugen Kinase 496Sgk496 |
| Cellular Localisation | CytoplasmCell MembraneApical Cell MembraneBasolateral Cell MembraneCell JunctionDetected At Apical Cell-Cell JunctionsColocalized With Fgf Receptors To The Cell MembraneDetected In Basolateral And Apical Membranes Of All Tubular Epithelia |
| Alternative Antibody Names | Anti-Dual Serine/Threonine And Tyrosine Protein Kinase antibodyAnti-Dusty Protein Kinase antibodyAnti-Dusty Pk antibodyAnti-Rip-Homologous Kinase antibodyAnti-Receptor-Interacting Serine/Threonine-Protein Kinase 5 antibodyAnti-Sugen Kinase 496 antibodyAnti-Sgk496 antibodyAnti-DSTYK antibodyAnti-KIAA0472 antibodyAnti-RIP5 antibodyAnti-RIPK5 antibodyAnti-SGK496 antibodyAnti-HDCMD38P antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
