| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNAJB11 (89-358) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNAJB11 |
| Gene ID: |
51726 |
| Uniprot ID: |
DJB11_HUMAN |
| Immunogen Region: |
89-358 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 89-358 of human DNAJB11 (NP_057390.1). |
| Immunogen Sequence: |
YGEEGLKDGHQSSHGDIFSH FFGDFGFMFGGTPRQQDRNI PRGSDIIVDLEVTLEEVYAG NFVEVVRNKPVARQAPGKRK CNCRQEMRTTQLGPGRFQMT QEVVCDECPNVKLVNEERTL EVEIEPGVRDGMEYPFIGEG EPHVDGEPGDLRFRIKVVKH PIFERRGDDLYTNVTISLVE SLVGFEMDITHLDGHKVHIS RDKITRPGAKLWKKGEGLPN FDNNNIKGSLIITFDVDFP |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Contains high-mannose Endo H-sensitive carbohydrates. Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known. Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR.however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven. |
| Function | As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. |
| Protein Name | Dnaj Homolog Subfamily B Member 11Apobec1-Binding Protein 2Abbp-2Dnaj Protein Homolog 9Er-Associated DnajEr-Associated Hsp40 Co-ChaperoneEndoplasmic Reticulum Dna J Domain-Containing Protein 3Er-Resident Protein Erdj3Erdj3Erj3pHedjHuman Dnaj Protein 9Hdj-9Pwp1-Interacting Protein 4 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum LumenAssociated With The Er Membrane In A C-Terminally Epitope-Tagged Construct |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily B Member 11 antibodyAnti-Apobec1-Binding Protein 2 antibodyAnti-Abbp-2 antibodyAnti-Dnaj Protein Homolog 9 antibodyAnti-Er-Associated Dnaj antibodyAnti-Er-Associated Hsp40 Co-Chaperone antibodyAnti-Endoplasmic Reticulum Dna J Domain-Containing Protein 3 antibodyAnti-Er-Resident Protein Erdj3 antibodyAnti-Erdj3 antibodyAnti-Erj3p antibodyAnti-Hedj antibodyAnti-Human Dnaj Protein 9 antibodyAnti-Hdj-9 antibodyAnti-Pwp1-Interacting Protein 4 antibodyAnti-DNAJB11 antibodyAnti-EDJ antibodyAnti-ERJ3 antibodyAnti-HDJ9 antibodyAnti-PSEC0121 antibodyAnti-UNQ537 antibodyAnti-PRO1080 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
