| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNAJB11 |
| Gene ID: | 51726 |
| Uniprot ID: | DJB11_HUMAN |
| Immunogen Region: | 89-358 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 89-358 of human DNAJB11 (NP_057390.1). |
| Immunogen Sequence: | YGEEGLKDGHQSSHGDIFSH FFGDFGFMFGGTPRQQDRNI PRGSDIIVDLEVTLEEVYAG NFVEVVRNKPVARQAPGKRK CNCRQEMRTTQLGPGRFQMT QEVVCDECPNVKLVNEERTL EVEIEPGVRDGMEYPFIGEG EPHVDGEPGDLRFRIKVVKH PIFERRGDDLYTNVTISLVE SLVGFEMDITHLDGHKVHIS RDKITRPGAKLWKKGEGLPN FDNNNIKGSLIITFDVDFP |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Contains high-mannose Endo H-sensitive carbohydrates. Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known. Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR.however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven. |
| Function | As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. |
| Protein Name | Dnaj Homolog Subfamily B Member 11 Apobec1-Binding Protein 2 Abbp-2 Dnaj Protein Homolog 9 Er-Associated Dnaj Er-Associated Hsp40 Co-Chaperone Endoplasmic Reticulum Dna J Domain-Containing Protein 3 Er-Resident Protein Erdj3 Erdj3 Erj3p Hedj Human Dnaj Protein 9 Hdj-9 Pwp1-Interacting Protein 4 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen Associated With The Er Membrane In A C-Terminally Epitope-Tagged Construct |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily B Member 11 antibody Anti-Apobec1-Binding Protein 2 antibody Anti-Abbp-2 antibody Anti-Dnaj Protein Homolog 9 antibody Anti-Er-Associated Dnaj antibody Anti-Er-Associated Hsp40 Co-Chaperone antibody Anti-Endoplasmic Reticulum Dna J Domain-Containing Protein 3 antibody Anti-Er-Resident Protein Erdj3 antibody Anti-Erdj3 antibody Anti-Erj3p antibody Anti-Hedj antibody Anti-Human Dnaj Protein 9 antibody Anti-Hdj-9 antibody Anti-Pwp1-Interacting Protein 4 antibody Anti-DNAJB11 antibody Anti-EDJ antibody Anti-ERJ3 antibody Anti-HDJ9 antibody Anti-PSEC0121 antibody Anti-UNQ537 antibody Anti-PRO1080 antibody |
Information sourced from Uniprot.org