| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DLGAP5 (547-846) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DLGAP5 |
| Gene ID: |
9787 |
| Uniprot ID: |
DLGP5_HUMAN |
| Immunogen Region: |
547-846 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 547-846 of human DLGAP5 (NP_055565.3). |
| Immunogen Sequence: |
KNVFRKKVVSGIASKPKQDD AGRIAARNRLAAIKNAMRER IRQEECAETAVSVIPKEVDK IVFDAGFFRVESPVKLFSGL SVSSEGPSQRLGTPKSVNKA VSQSRNEMGIPQQTTSPENA GPQNTKSEHVKKTLFLSIPE SRSSIEDAQCPGLPDLIEEN HVVNKTDLKVDCLSSERMSL PLLAGGVADDINTNKKEGIS DVVEGMELNSSITSQDVLMS SPEKNTASQNSILEEGETK |
| Tissue Specificity | Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. |
| Post Translational Modifications | Ubiquitinated, leading to its degradation. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells. |
| Function | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. |
| Protein Name | Disks Large-Associated Protein 5Dap-5Discs Large Homolog 7Disks Large-Associated Protein Dlg7Hepatoma Up-Regulated ProteinHurp |
| Database Links | Reactome: R-HSA-9013508 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleLocalizes To The Spindle In Mitotic CellsColocalizes With Cdh1 At Sites Of Cell-Cell Contact In Intestinal Epithelial Cells |
| Alternative Antibody Names | Anti-Disks Large-Associated Protein 5 antibodyAnti-Dap-5 antibodyAnti-Discs Large Homolog 7 antibodyAnti-Disks Large-Associated Protein Dlg7 antibodyAnti-Hepatoma Up-Regulated Protein antibodyAnti-Hurp antibodyAnti-DLGAP5 antibodyAnti-DLG7 antibodyAnti-KIAA0008 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
