| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DIS3 (1-280) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DIS3 |
| Gene ID: |
22894 |
| Uniprot ID: |
RRP44_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DIS3 (NP_055768.3). |
| Immunogen Sequence: |
MLKSKTFLKKTRAGGVMKIV REHYLRDDIGCGAPGCAACG GAHEGPALEPQPQDPASSVC PQPHYLLPDTNVLLHQIDVL EDPAIRNVIVLQTVLQEVRN RSAPVYKRIRDVTNNQEKHF YTFTNEHHRETYVEQEQGEN ANDRNDRAIRVAAKWYNEHL KKMSADNQLQVIFITNDRRN KEKAIEEGIPAFTCEEYVKS LTANPELIDRLACLSEEGNE IESGKIIFSEHLPLSKLQQ |
| Tissue Specificity | Widely expressed. |
| Function | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. |
| Protein Name | Exosome Complex Exonuclease Rrp44Protein Dis3 HomologRibosomal Rna-Processing Protein 44 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429958Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-450604Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmPredominantly Located In The NucleusFound In The NucleolusExcluded From Nucleolus Supporting The Existence Of A Nucleolar Rna Exosome Complex Devoid Of Dis3 |
| Alternative Antibody Names | Anti-Exosome Complex Exonuclease Rrp44 antibodyAnti-Protein Dis3 Homolog antibodyAnti-Ribosomal Rna-Processing Protein 44 antibodyAnti-DIS3 antibodyAnti-KIAA1008 antibodyAnti-RRP44 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
