| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEFA4 (40-97) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEFA4 |
| Gene ID: |
1669 |
| Uniprot ID: |
DEF4_HUMAN |
| Immunogen Region: |
40-97 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 40-97 of human DEFA4 (NP_001916.1). |
| Immunogen Sequence: |
QDISISFAWDKSSALQVSGS TRGMVCSCRLVFCRRTELRV GNCLIGGVSFTYCCTRVD |
| Tissue Specificity | Expressed in neutrophils (at protein level). Expressed in bone marrow. |
| Post Translational Modifications | The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for effective bacterial killing. |
| Function | Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef. Protects blood cells against infection with HIV-1 (in vitro). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro). |
| Protein Name | Defensin Alpha 4Corticostatin Hp-4Hnp-4Hp-4Neutrophil Defensin 4 |
| Database Links | Reactome: R-HSA-1461973Reactome: R-HSA-1462054Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedCytoplasmic VesicleSecretory VesicleStored As Mature Peptide In Neutrophil Granules |
| Alternative Antibody Names | Anti-Defensin Alpha 4 antibodyAnti-Corticostatin Hp-4 antibodyAnti-Hnp-4 antibodyAnti-Hp-4 antibodyAnti-Neutrophil Defensin 4 antibodyAnti-DEFA4 antibodyAnti-DEF4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
