| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEFA3 (20-94) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEFA3 |
| Gene ID: |
1668 |
| Uniprot ID: |
DEF3_HUMAN |
| Immunogen Region: |
20-94 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-94 of human DEFA3 (NP_005208.1). |
| Immunogen Sequence: |
EPLQARADEVAAAPEQIAAD IPEVVVSLAWDESLAPKHPG SRKNMDCYCRIPACIAGERR YGTCIYQGRLWAFCC |
| Function | Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses. Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus. Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment. |
| Protein Name | Neutrophil Defensin 3Defensin - Alpha 3Hnp-3Hp-3Hp3 Cleaved Into - Hp 3-56 - Neutrophil Defensin 2Hnp-2Hp-2Hp2 |
| Database Links | Reactome: R-HSA-1461973Reactome: R-HSA-1462054 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neutrophil Defensin 3 antibodyAnti-Defensin - Alpha 3 antibodyAnti-Hnp-3 antibodyAnti-Hp-3 antibodyAnti-Hp3 Cleaved Into - Hp 3-56 - Neutrophil Defensin 2 antibodyAnti-Hnp-2 antibodyAnti-Hp-2 antibodyAnti-Hp2 antibodyAnti-DEFA3 antibodyAnti-DEF3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
