Western blot analysis of extracts of various cell lines, using DEFA3 antibody (STJ27293) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Anti-DEFA3 antibody (20-94) (STJ27293)

SKU:
STJ27293
$151.88 - $708.08
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DEFA3
Gene ID: 1668
Uniprot ID: DEF3_HUMAN
Immunogen Region: 20-94
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 20-94 of human DEFA3 (NP_005208.1).
Immunogen Sequence: EPLQARADEVAAAPEQIAAD IPEVVVSLAWDESLAPKHPG SRKNMDCYCRIPACIAGERR YGTCIYQGRLWAFCC
Function Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses. Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus. Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment.
Protein Name Neutrophil Defensin 3
Defensin - Alpha 3
Hnp-3
Hp-3
Hp3 Cleaved Into - Hp 3-56 - Neutrophil Defensin 2
Hnp-2
Hp-2
Hp2
Database Links Reactome: R-HSA-1461973
Reactome: R-HSA-1462054
Cellular Localisation Secreted
Alternative Antibody Names Anti-Neutrophil Defensin 3 antibody
Anti-Defensin - Alpha 3 antibody
Anti-Hnp-3 antibody
Anti-Hp-3 antibody
Anti-Hp3 Cleaved Into - Hp 3-56 - Neutrophil Defensin 2 antibody
Anti-Hnp-2 antibody
Anti-Hp-2 antibody
Anti-Hp2 antibody
Anti-DEFA3 antibody
Anti-DEF3 antibody

Information sourced from Uniprot.org

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