| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYTH2 (150-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYTH2 |
| Gene ID: |
9266 |
| Uniprot ID: |
CYH2_HUMAN |
| Immunogen Region: |
150-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human CYTH2 (NP_059431.1). |
| Immunogen Sequence: |
SFRLPGEAQKIDRMMEAFAQ RYCLCNPGVFQSTDTCYVLS FAVIMLNTSLHNPNVRDKPG LERFVAMNRGINEGGDLPEE LLRNLYDSIRNEPFKIPEDD GNDLTHTFFNPDREGWLLKL GGGRVKTWKRRWFILTDNCL YYFEYTTDKEPRGIIPLENL SIREVDDPRKPNCFELYIPN NKGQLIKACKTEADGRVVEG N |
| Tissue Specificity | Widely expressed. |
| Function | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. |
| Protein Name | Cytohesin-2Arf Exchange FactorArf Nucleotide-Binding Site OpenerProtein ArnoPh - Sec7 And Coiled-Coil Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-6811438 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmCell ProjectionGrowth ConeCell JunctionTight JunctionAdherens JunctionBoth Isoform 1 And Isoform 2 Are Recruited To The Cell Membrane Through Its Association With Arl4aArl4c And Arl4dThey Require Also Interaction With Phosphoinositides For Targeting To Plasma MembraneIn Differentiating Neuroblastoma CellsColocalizes With Ccdc120 In Both Neurite Shaft And Growth Cone Areas |
| Alternative Antibody Names | Anti-Cytohesin-2 antibodyAnti-Arf Exchange Factor antibodyAnti-Arf Nucleotide-Binding Site Opener antibodyAnti-Protein Arno antibodyAnti-Ph - Sec7 And Coiled-Coil Domain-Containing Protein 2 antibodyAnti-CYTH2 antibodyAnti-ARNO antibodyAnti-PSCD2 antibodyAnti-PSCD2L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
