| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP4F2 (40-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP4F2 |
| Gene ID: |
8529 |
| Uniprot ID: |
CP4F2_HUMAN |
| Immunogen Region: |
40-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human CYP4F2 (NP_001073.3). |
| Immunogen Sequence: |
AFYDNCRRLRCFPQPPRRNW FWGHQGMVNPTEEGMRVLTQ LVATYPQGFKVWMGPISPLL SLCHPDIIRSVINASAAIAP K |
| Tissue Specificity | Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs. Catalyzes omega-hydroxylation of 3-hydroxy fatty acids. Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites. Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening. Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues. Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. |
| Protein Name | Cytochrome P450 4f220-Hydroxyeicosatetraenoic Acid Synthase20-Hete SynthaseArachidonic Acid Omega-HydroxylaseCypivf2Cytochrome P450-Ltb-OmegaDocosahexaenoic Acid Omega-HydroxylaseLeukotriene-B(4 20-Monooxygenase 1Leukotriene-B(4 Omega-Hydroxylase 1Phylloquinone Omega-Hydroxylase Cyp4f2 |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211979Reactome: R-HSA-2142691Reactome: R-HSA-2142816 |
| Cellular Localisation | Microsome MembranePeripheral Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4f2 antibodyAnti-20-Hydroxyeicosatetraenoic Acid Synthase antibodyAnti-20-Hete Synthase antibodyAnti-Arachidonic Acid Omega-Hydroxylase antibodyAnti-Cypivf2 antibodyAnti-Cytochrome P450-Ltb-Omega antibodyAnti-Docosahexaenoic Acid Omega-Hydroxylase antibodyAnti-Leukotriene-B(4 20-Monooxygenase 1 antibodyAnti-Leukotriene-B(4 Omega-Hydroxylase 1 antibodyAnti-Phylloquinone Omega-Hydroxylase Cyp4f2 antibodyAnti-CYP4F2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
