| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP2J2 (264-277) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2J2 |
| Gene ID: |
1573 |
| Uniprot ID: |
CP2J2_HUMAN |
| Immunogen Region: |
264-277 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 264-277 of human CYP2J2 (NP_000766.2). |
| Immunogen Sequence: |
KHRKDWNPAETRDF |
| Tissue Specificity | Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level). |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of PUFA. Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools. In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent. Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone. Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole. Catalyzes the sulfoxidation of fenbedazole. |
| Protein Name | Cytochrome P450 2j2Albendazole MonooxygenaseHydroxylatingAlbendazole MonooxygenaseSulfoxide-FormingArachidonic Acid EpoxygenaseCypiij2Hydroperoxy Icosatetraenoate Isomerase |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211981Reactome: R-HSA-2142670 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2j2 antibodyAnti-Albendazole Monooxygenase antibodyAnti-Hydroxylating antibodyAnti-Albendazole Monooxygenase antibodyAnti-Sulfoxide-Forming antibodyAnti-Arachidonic Acid Epoxygenase antibodyAnti-Cypiij2 antibodyAnti-Hydroperoxy Icosatetraenoate Isomerase antibodyAnti-CYP2J2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
