| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CYP2D6 (341-497) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S2MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2D6 |
| Gene ID: |
1565 |
| Uniprot ID: |
CP2D6_HUMAN |
| Immunogen Region: |
341-497 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 341-497 of human CYP2D6 (P10635). |
| Immunogen Sequence: |
QVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSR DIEVQGFRIPKGTTLITNLS SVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGR RACLGEPLARMELFLFFTSL LQHFSFSVPTGQPRPSHHGV FAFLVSPSPYELCAVPR |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. |
| Protein Name | Cytochrome P450 2d6Cypiid6Cholesterol 25-HydroxylaseCytochrome P450-Db1Debrisoquine 4-Hydroxylase |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-9027307Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2d6 antibodyAnti-Cypiid6 antibodyAnti-Cholesterol 25-Hydroxylase antibodyAnti-Cytochrome P450-Db1 antibodyAnti-Debrisoquine 4-Hydroxylase antibodyAnti-CYP2D6 antibodyAnti-CYP2DL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
