| Host: |
Mouse |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-cTnT (121-133) is suitable for use in ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
3708 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Purification: |
Greater than 95% purity |
| Concentration: |
5.0 mg/ml (+/-10 %) |
| Storage Instruction: |
Unspecified, storage at 2–8°C. Temperature analysis:-70 °C, 21 days Not Determined (N/D)-20 °C, 14 days OK +4 °C, 14 days OK +35 °C, 14 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer. |
| Association Rate Constant: |
2.1 x 106 1/Ms |
| Determination Method: |
SPR analysis (ProteOn XPR36) |
| Immunoreactivity: |
80–120 % compared to the reference sample in an FIA test |
| Gene Symbol: |
TNNT2 |
| Gene ID: |
7139 |
| Uniprot ID: |
TNNT2_HUMAN |
| Immunogen Region: |
121-133 |
| Immunogen: |
Human cardiac troponin T (cTnT) |
| Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Post Translational Modifications | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin T - Cardiac MuscleTntcCardiac Muscle Troponin TCtnt |
| Database Links | Reactome: R-HSA-390522 |
| Alternative Antibody Names | Anti-Troponin T - Cardiac Muscle antibodyAnti-Tntc antibodyAnti-Cardiac Muscle Troponin T antibodyAnti-Ctnt antibodyAnti-TNNT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
