| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNNT2 |
| Gene ID: | 7139 |
| Uniprot ID: | TNNT2_HUMAN |
| Immunogen Region: | 1-288 |
| Specificity: | Recombinant Protein corresponding to a sequence within amino acids 1-288 of human cTNT (NP_001001430.1). |
| Immunogen Sequence: | MSDIEEVVEEYEEEEQEEAA VEEQEEAAEEDAEAEAETEE TRAEEDEEEEEAKEAEDGPM EESKPKPRSFMPNLVPPKIP DGERVDFDDIHRKRMEKDLN ELQALIEAHFENRKKEEEEL VSLKDRIERRRAERAEQQRI RNEREKERQNRLAEERARRE EEENRRKAEDEARKKKALSN MMHFGGYIQKQAQTERKSGK RQTEREKKKKILAERRKVLA IDHLNEDQLREKAKELWQS |
| Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Post Translational Modifications | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin T - Cardiac MuscleTntcCardiac Muscle Troponin TCtnt |
| Database Links | Reactome: R-HSA-390522 |
| Alternative Antibody Names | Anti-Troponin T - Cardiac Muscle antibodyAnti-Tntc antibodyAnti-Cardiac Muscle Troponin T antibodyAnti-Ctnt antibodyAnti-TNNT2 antibody |
Information sourced from Uniprot.org