Anti-CSE1L antibody (1-50 aa) (STJ92006)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CSE1L at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Exportin-2 (1-50 aa) for use in WB, IHC, IP, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IP/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IP 2-5 ug mg/lysateIF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSE1L |
| Gene ID | 1434 |
| Uniprot ID | XPO2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CSE1L at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | CAS Polyclonal Antibody detects endogenous levels of CAS protein. |
Additional Info
| Function | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Exportin-2Exp2Cellular Apoptosis Susceptibility ProteinChromosome Segregation 1-Like ProteinImportin-Alpha Re-Exporter |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-2 antibodyAnti-Exp2 antibodyAnti-Cellular Apoptosis Susceptibility Protein antibodyAnti-Chromosome Segregation 1-Like Protein antibodyAnti-Importin-Alpha Re-Exporter antibodyAnti-CSE1L antibodyAnti-CAS antibodyAnti-XPO2 antibody |
Information sourced from Uniprot.org