| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CRHR1 (24-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CRHR1 |
| Gene ID: |
104909134/1394 |
| Uniprot ID: |
CRFR1_HUMAN |
| Immunogen Region: |
24-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1). |
| Immunogen Sequence: |
SLQDQHCESLSLASNISGLQ CNASVDLIGTCWPRSPAGQL VVRPCPAFFYGVRYNTTNNG YRECLANGSWAARVNYSECQ EILNEEKKSKVHYHVAV |
| Tissue Specificity | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. |
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Protein Name | Corticotropin-Releasing Factor Receptor 1Crf-R-1Crf-R1Crfr-1Corticotropin-Releasing Hormone Receptor 1Crh-R-1Crh-R1 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosomeAgonist-Binding Promotes Endocytosis |
| Alternative Antibody Names | Anti-Corticotropin-Releasing Factor Receptor 1 antibodyAnti-Crf-R-1 antibodyAnti-Crf-R1 antibodyAnti-Crfr-1 antibodyAnti-Corticotropin-Releasing Hormone Receptor 1 antibodyAnti-Crh-R-1 antibodyAnti-Crh-R1 antibodyAnti-CRHR1 antibodyAnti-CRFR antibodyAnti-CRFR1 antibodyAnti-CRHR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
