| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CREBBP (1-445) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CrebbpUniprot ID=CBP_MOUSE" |
| Immunogen Region: |
1-445 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-445 of mouse CREBBP (NP_001020603.1). |
| Immunogen Sequence: |
MAENLLDGPPNPKRAKLSSP GFSANDNTDFGSLFDLENDL PDELIPNGELSLLNSGNLVP DAASKHKQLSELLRGGSGSS INPGIGNVSASSPVQQGLGG QAQGQPNSTNMASLGAMGKS PLNQGDSSTPNLPKQAASTS GPTPPASQALNPQAQKQVGL VTSSPATSQTGPGICMNANF NQTHPGLLNSNSGHSLMNQA QQGQAQVMNGSLGAAGRGRG AGMPYPAPAMQGATSSVLA |
| Post Translational Modifications | Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated by CHUK/IKKA at Ser-1383 and Ser-1387.these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53. Autoacetylation is induced by glucose and fatty acids. |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway. |
| Protein Name | Histone Lysine Acetyltransferase CrebbpProtein-Lysine Acetyltransferase Crebbp |
| Cellular Localisation | CytoplasmNucleusRecruited To Nuclear Bodies By Ss18l1/CrestIn The Presence Of Alx1 Relocalizes From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Histone Lysine Acetyltransferase Crebbp antibodyAnti-Protein-Lysine Acetyltransferase Crebbp antibodyAnti-Crebbp antibodyAnti-Cbp antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
