| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FLJ12529 (50-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPSF7 |
| Gene ID: |
79869 |
| Uniprot ID: |
CPSF7_HUMAN |
| Immunogen Region: |
50-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human FLJ12529 (NP_079087.3). |
| Immunogen Sequence: |
LIDIYADEEFNQDPEFNNTD QIDLYDDVLTATSQPSDDRS SSTEPPPPVRQEPSPKPNNK TPAILYTYSGLRNRRAAVYV GSFSWWTTDQQLIQVIRSIG VYDVVELKFAENRANGQSKG YAEVVVASENSVHKLLELLP GKVLNGEKVDVRPATRQNLS QFEAQARKRECVRVPRGGIP PRAHSRDSSDS |
| Post Translational Modifications | Phosphorylated. Asymmetrically dimethylated on arginine residues by PRMT1. |
| Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. |
| Protein Name | Cleavage And Polyadenylation Specificity Factor Subunit 7Cleavage And Polyadenylation Specificity Factor 59 Kda SubunitCpsf 59 Kda SubunitCleavage Factor Im Complex 59 Kda SubunitCfim59Pre-Mrna Cleavage Factor Im 59 Kda Subunit |
| Database Links | Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm In A Transcription- And Xpo1/Crm1-Independent MannerMost Probably In Complex With The Cleavage Factor Im Complex (Cfim) |
| Alternative Antibody Names | Anti-Cleavage And Polyadenylation Specificity Factor Subunit 7 antibodyAnti-Cleavage And Polyadenylation Specificity Factor 59 Kda Subunit antibodyAnti-Cpsf 59 Kda Subunit antibodyAnti-Cleavage Factor Im Complex 59 Kda Subunit antibodyAnti-Cfim59 antibodyAnti-Pre-Mrna Cleavage Factor Im 59 Kda Subunit antibodyAnti-CPSF7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
