| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CPLX3 (59-158) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPLX3 |
| Gene ID: |
594855 |
| Uniprot ID: |
CPLX3_HUMAN |
| Immunogen Region: |
59-158 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 59-158 of human CPLX3 (NP_001025176.1). |
| Immunogen Sequence: |
DAQFTQRKAERATLRSHFRD KYRLPKNETDESQIQMAGGD VELPRELAKMIEEDTEEEEE KASVLGQLASLPGLNLGSLK DKAQATLGDLKQSAEKCHVM |
| Post Translational Modifications | Farnesylation mediates presynaptic targeting. |
| Function | Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release. |
| Protein Name | Complexin-3Complexin IiiCpx Iii |
| Cellular Localisation | SynapseCell MembraneLipid-AnchorEnriched At The Synaptic TerminalLocalized At Glycinergic Synaptic Contacts Of Aii Amacrine Cells With Off Cone Bipolar Cells In The Off Sublamina Of The Retina Inner Nuclear Layer |
| Alternative Antibody Names | Anti-Complexin-3 antibodyAnti-Complexin Iii antibodyAnti-Cpx Iii antibodyAnti-CPLX3 antibodyAnti-Nbla11589 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
