| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COQ6 (169-468) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COQ6 |
| Gene ID: |
51004 |
| Uniprot ID: |
COQ6_HUMAN |
| Immunogen Region: |
169-468 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 169-468 of human COQ6 (NP_872282.1). |
| Immunogen Sequence: |
SKAIRYTWPCPFPMADSSPW VHITLGDGSTFQTKLLIGAD GHNSGVRQAVGIQNVSWNYD QSAVVATLHLSEATENNVAW QRFLPSGPIALLPLSDTLSS LVWSTSHEHAAELVSMDEEK FVDAVNSAFWSDADHTDFID TAGAMLQYAVSLLKPTKVSA RQLPPSVARVDAKSRVLFPL GLGHAAEYVRPRVALIGDAA HRVHPLAGQGVNMGFGDISS LAHHLSTAAFNGKDLGSVS |
| Tissue Specificity | Widely expressed. |
| Function | FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown. |
| Protein Name | Ubiquinone Biosynthesis Monooxygenase Coq6 - MitochondrialCoenzyme Q10 Monooxygenase 6 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideGolgi ApparatusCell ProjectionLocalizes To Cell Processes And Golgi Apparatus In Podocytes |
| Alternative Antibody Names | Anti-Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial antibodyAnti-Coenzyme Q10 Monooxygenase 6 antibodyAnti-COQ6 antibodyAnti-CGI-10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
