| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNTNAP2 |
| Gene ID: | 26047 |
| Uniprot ID: | CNTP2_HUMAN |
| Immunogen Region: | 180-400 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human Caspr2/Caspr2/CNTNAP2 (NP_054860.1). |
| Immunogen Sequence: | GCSYWADVINFDGHVVLPYR FRNKKMKTLKDVIALNFKTS ESEGVILHGEGQQGDYITLE LKKAKLVLSLNLGSNQLGPI YGHTSVMTGSLLDDHHWHSV VIERQGRSINLTLDRSMQHF RTNGEFDYLDLDYEITFGGI PFSGKPSSSSRKNFKGCMES INYNGVNITDLARRKKLEPS NVGNLSFSCVEPYTVPVFFN ATSYLEVPGRLNQDLFSVSF Q |
| Tissue Specificity | Predominantly expressed in nervous system. |
| Function | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. |
| Protein Name | Contactin-Associated Protein-Like 2Cell Recognition Molecule Caspr2 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonCell JunctionParanodal Septate JunctionExpressed In The Juxtaparadonal Region |
| Alternative Antibody Names | Anti-Contactin-Associated Protein-Like 2 antibodyAnti-Cell Recognition Molecule Caspr2 antibodyAnti-CNTNAP2 antibodyAnti-CASPR2 antibodyAnti-KIAA0868 antibody |
Information sourced from Uniprot.org