| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CNTNAP1 (20-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNTNAP1 |
| Gene ID: |
8506 |
| Uniprot ID: |
CNTP1_HUMAN |
| Immunogen Region: |
20-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human Caspr1 (NP_003623.1). |
| Immunogen Sequence: |
WGYYGCDEELVGPLYARSLG ASSYYSLLTAPRFARLHGIS GWSPRIGDPNPWLQIDLMKK HRIRAVATQGSFNSWDWVTR YMLLYGDRVDSWTPFYQRGH NSTFFGNVNESAVVRHDLHF HFTARYIRIVPLAWNPRGKI GLRLGLYGCPYKADILYFDG DDAISYRFPRGVSRSLWDVF AFSFKTEEKDGLLLHAEGAQ GDYVTLELEGAHLLLHMSLG SSPIQPRPGHTTVSAGGVL |
| Tissue Specificity | Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. |
| Function | Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. |
| Protein Name | Contactin-Associated Protein 1CasprCaspr1Neurexin IvNeurexin-4P190 |
| Database Links | Reactome: R-HSA-447043 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionParanodal Septate Junction |
| Alternative Antibody Names | Anti-Contactin-Associated Protein 1 antibodyAnti-Caspr antibodyAnti-Caspr1 antibodyAnti-Neurexin Iv antibodyAnti-Neurexin-4 antibodyAnti-P190 antibodyAnti-CNTNAP1 antibodyAnti-CASPR antibodyAnti-NRXN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
