• Western blot analysis of normal 293T cells and 293T transfected with CNMD protein, using CNMD Rabbit polyclonal antibody (STJ11105237) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CNMD antibody (STJ11105237)

SKU:
STJ11105237

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Leukocyte Cell-Derived Chemotaxin 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNMD
Gene ID: 11061
Uniprot ID: CNMD_HUMAN
Immunogen: Recombinant protein of human CNMD.
Immunogen Sequence: VHYTMSINGKLQDGSMEIDA GNNLETFKMGSGAEEAIAVN DFQNGITGIRFAGGEKCYIK AQVKARIPEVGAVTKQSISS KLEGKIMPVKYEENSLIWVA VDQPVKDNSFLSSKVLELCG DLPIFWLKPTYPKEIQRERR EVVRKIVPTTTKRPHSGPRS NPGAGRLNNETRPSVQEDSQ AFNPDNPYHQQEGESMTFDP RLDHEGICCIECRRSYTHCQ KICEPLGGYYPWPYNYQGC
Tissue Specificity Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
Post Translational Modifications After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
Function Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
Protein Name Leukocyte Cell-Derived Chemotaxin 1
Chondromodulin Cleaved Into - Chondrosurfactant Protein
Ch-Sp - Chondromodulin-1
Chondromodulin-I
Chm-I
Cellular Localisation Chondromodulin-1: Secreted
Extracellular Space
Extracellular Matrix
Accumulated In The Inter-Territorial Matrix Of Cartilage
Chondrosurfactant Protein: Endomembrane System
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Leukocyte Cell-Derived Chemotaxin 1 antibody
Anti-Chondromodulin Cleaved Into - Chondrosurfactant Protein antibody
Anti-Ch-Sp - Chondromodulin-1 antibody
Anti-Chondromodulin-I antibody
Anti-Chm-I antibody
Anti-CNMD antibody
Anti-CHMI antibody
Anti-LECT1 antibody
Anti-MYETS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance