• Western blot analysis of various lysates using CNGA4 Rabbit polyclonal antibody (STJ116920) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-CNGA4 antibody (416-575) (STJ116920)

SKU:
STJ116920

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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNGA4
Gene ID: 1262
Uniprot ID: CNGA4_HUMAN
Immunogen Region: 416-575
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1).
Immunogen Sequence: ISIINIKGNMSGNRRTANIK SLGYSDLFCLSKEDLREVLS EYPQAQTIMEEKGREILLKM NKLDVNAEAAEIALQEATES RLRGLDQQLDDLQTKFARLL AELESSALKIAYRIERLEWQ TREWPMPEDLAEADDEGEPE EGTSKDEEGRASQEGPPGPE
Function Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.
Protein Name Cyclic Nucleotide-Gated Channel Alpha-4
Cng Channel Alpha-4
Cnga4
Olfactory Cyclic Nucleotide-Gated Channel Subunit 2
Ocnc2
Database Links Reactome: R-HSA-381753
Reactome: R-HSA-5620916
Cellular Localisation Cell Projection
Cilium Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Cyclic Nucleotide-Gated Channel Alpha-4 antibody
Anti-Cng Channel Alpha-4 antibody
Anti-Cnga4 antibody
Anti-Olfactory Cyclic Nucleotide-Gated Channel Subunit 2 antibody
Anti-Ocnc2 antibody
Anti-CNGA4 antibody

Information sourced from Uniprot.org

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