| Post Translational Modifications | Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. |
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. |
| Protein Name | Calsyntenin-2Alcadein-GammaAlc-Gamma |
| Cellular Localisation | Postsynaptic Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCell ProjectionDendriteMost Prominent In The Postsynaptic Specializations Of Asymmetric (Type I) Synapses With Both Axodendritic And Axospinous Localization |
| Alternative Antibody Names | Anti-Calsyntenin-2 antibodyAnti-Alcadein-Gamma antibodyAnti-Alc-Gamma antibodyAnti-CLSTN2 antibodyAnti-CS2 antibody |
Information sourced from Uniprot.org
