| Tissue Specificity | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. |
| Protein Name | Chloride Intracellular Channel Protein 4Glutaredoxin-Like Oxidoreductase Clic4Intracellular Chloride Ion Channel Protein P64h1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Vesicle MembraneSingle-Pass Membrane ProteinNucleusCell MembraneMitochondrionCell JunctionEndoplasmic Reticulum MembraneColocalized With Akap9 At The Centrosome And MidbodyExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainPresent In An Intracellular Vesicular Compartment That Likely Represent Trans-Golgi Network VesiclesMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 4 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic4 antibodyAnti-Intracellular Chloride Ion Channel Protein P64h1 antibodyAnti-CLIC4 antibody |
Information sourced from Uniprot.org
