| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Inter-alpha-trypsin inhibitor heavy chain H4-R661 (612-661 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITIH4 |
| Gene ID: |
3700 |
| Uniprot ID: |
ITIH4_HUMAN |
| Immunogen Region: |
612-661 aa |
| Specificity: |
Cleaved-ITI-H4 70k (R661) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H4 70k protein resulting from cleavage adjacent to R661. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human ITIH4 at the amino acid range 612-661 |
| Post Translational Modifications | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
| Function | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H4Iti Heavy Chain H4Iti-Hc4Inter-Alpha-Inhibitor Heavy Chain 4Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related ProteinIhrpPlasma Kallikrein Sensitive Glycoprotein 120Gp120Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-Iti Heavy Chain H4 antibodyAnti-Iti-Hc4 antibodyAnti-Inter-Alpha-Inhibitor Heavy Chain 4 antibodyAnti-Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein antibodyAnti-Ihrp antibodyAnti-Plasma Kallikrein Sensitive Glycoprotein 120 antibodyAnti-Gp120 antibodyAnti-Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-ITIH4 antibodyAnti-IHRP antibodyAnti-ITIHL1 antibodyAnti-PK120 antibodyAnti-PRO1851 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
