| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN7 (626-805) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN7 |
| Gene ID: |
1186 |
| Uniprot ID: |
CLCN7_HUMAN |
| Immunogen Region: |
626-805 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 626-805 of human CLCN7 (NP_001278.1). |
| Immunogen Sequence: |
TAREVMSTPVTCLRRREKVG VIVDVLSDTASNHNGFPVVE HADDTQPARLQGLILRSQLI VLLKHKVFVERSNLGLVQRR LRLKDFRDAYPRFPPIQSIH VSQDERECTMDLSEFMNPSP YTVPQEASLPRVFKLFRALG LRHLVVVDNRNQVVGLVTRK DLARYRLGKRGLEELSLAQT |
| Tissue Specificity | Brain and kidney. |
| Function | Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. |
| Protein Name | H(+/Cl(- Exchange Transporter 7Chloride Channel 7 Alpha SubunitChloride Channel Protein 7Clc-7 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 7 antibodyAnti-Chloride Channel 7 Alpha Subunit antibodyAnti-Chloride Channel Protein 7 antibodyAnti-Clc-7 antibodyAnti-CLCN7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
